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Concentration–Adverse Reaction Associations You will find there's romance in between expanding codeine plasma focus and expanding frequency of dose-related opioid adverse reactions for example nausea, vomiting, CNS consequences, and respiratory despair.

A domestic teaspoon is not an accurate measuring gadget and could lead to overdosage [see Warnings and Precautions (5.seven)]. For prescriptions where a measuring gadget just isn't delivered, a pharmacist can offer an correct measuring device and can provide Guidance for measuring the proper dose. Never overfill. Rinse the measuring machine with water immediately after Each individual use.

Go through the Medication Guidebook supplied by your pharmacist Before you begin having promethazine/phenylephrine/codeine and every time you obtain a refill. Should you have any inquiries, talk to your physician or pharmacist.

Codeine Codeine and its Energetic metabolite, morphine, are present in human milk. You will discover published research and cases which have reported excessive sedation, respiratory depression and Loss of life (in a single infant) in infants exposed to codeine via breast milk. Females who are extremely-fast metabolizers of codeine obtain greater than predicted serum levels of morphine, possibly bringing about larger levels of morphine in breast milk that could be hazardous in their breastfed infants.

Your Health care service provider may possibly do blood checks to look for adrenal gland troubles. Call your healthcare service provider straight away When you've got any of these signs or symptoms:

It is soluble in water and freely soluble in alcohol. The molecular bodyweight is 320.88. Its molecular method is C17H20N2S•HCl, and it's the next chemical structure.

If another person has overdosed and has really serious signs for instance passing out or difficulty respiration, get in touch with 911. Otherwise, get in touch with a poison Manage Heart straight away.

Revealed scientific tests with codeine have noted inconsistent conclusions and have critical methodological limits (see Data). You'll find reviews of respiratory depression when codeine is employed all through labor and supply (see Medical Things to consider).

This may be associated with a decrease in efficacy, and in a few individuals, may bring about symptoms and signs or symptoms of opioid withdrawal.

5.seven Hazards of Accidental Overdose and Dying on account of Medication Errors Dosing problems can result in accidental overdose and Demise. To reduce the chance of overdose and fishscale copyright respiratory despair, make sure that the dose of promethazine HCl and codeine phosphate oral Alternative is communicated clearly and dispensed correctly [see Dosage and Administration (two.one)]. Advise sufferers to normally use an accurate milliliter measuring product when measuring and administering promethazine HCl and codeine phosphate oral Answer.

MAOI Conversation Advise patients not to consider promethazine HCl and codeine phosphate oral Remedy even though working with or within 14 days of stopping any medications that inhibit monoamine oxidase.

Codeine is thought to be considerably excreted via the kidney, and the potential risk of adverse reactions to this drug can be higher in sufferers with impaired renal functionality.

Exactly where do calls go? Phone calls to quantities on a certain treatment method Middle listing is going to be routed to that treatment method Middle. Calls to the web site’s key cell phone number is going to be answered or returned by one of several treatment method companies outlined below, Each individual of and that is a paid out advertiser:

Tend not to flush drugs down the toilet or pour them into a drain Unless of course instructed to take action. Adequately discard this merchandise when it really is expired or no longer wanted. Talk to your pharmacist or nearby squander disposal organization.